Uncooperative immune cells
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چکیده
منابع مشابه
Uncooperative immune cells
JCB • VOLUME 167 • NUMBER 2 • 2004 190 A chaperone feels the heat chaperone is supposed to keep its cool when temperatures get hot. But Syed Rizvi, Laura Mancino, Malini Raghavan (University of Michigan, Ann Arbor, MI), and colleagues show that calreticulin—a glycoprotein chaperone—starts to melt in the heat. The resulting structural changes actually improve its chaperone activity and may also ...
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A typical voltage-gated potassium (Kv) or sodium channel is exquisitely sensitive to small changes of membrane potential, so much so that a depolarization of <5 mV can increase its open probability by an order of magnitude. The high sensitivity is crucial for the rapid generation and propagation of action potentials in excitable cells. Optimizing sensitivity to membrane potential requires some ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1672rr3